Action mechanism of metallo-allixin complexes as antidiabetic agents

Autor:	Makoto Hiromura, Hiromu Sakurai
Rok vydání:	2008
Předmět:	Mechanism (biology) General Chemical Engineering Insulin medicine.medical_treatment General Chemistry Pharmacology medicine.disease Allixin chemistry.chemical_compound Biochemistry chemistry Adipocyte Diabetes mellitus medicine Lipolysis Secretion Metabolic syndrome
Zdroj:	Pure and Applied Chemistry. 80:2727-2733
ISSN:	1365-3075 0033-4545
DOI:	10.1351/pac200880122727
Popis:	The metabolic syndrome is a group of factors associated with an increased risk of atherosclerosis and diabetes. Diabetes mellitus (DM) is classified into 2 major types - type 1 DM and type 2 DM - characterized by chronic hyperglycemia resulting from defects in insulin secretion and insulin action, respectively. Several synthetic pharmaceuticals have been developed and clinically used for treating DM; however, these pharmaceuticals continue to cause side effects. Recently, we proposed that oxovanadium(IV) (vanadyl) and zinc(II) (zinc) complexes are potent antidiabetic agents for both type 1 and type 2 DM therapy. This article reviews the vanadyl- and zinc-allixin and their related complexes that are being currently developed as novel types of antidiabetic metal complexes, focusing on their action mechanism in terms of regulation of the insulin signaling pathway and inhibition of lipolysis signaling in adipocyte cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d807baca9ae65f52311708b8483b395a https://doi.org/10.1351/pac200880122727 Zobrazit plný text záznamu Plný text ve formátu PDF