| Autor: |
Takallapalli Ramesh Kumar Rao, Sunil Kumar Reddy Khambam, Pingali Usha Rani, Madireddy Umamaheshwar Rao Naidu |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
International Journal of Nutrition, Pharmacology, Neurological Diseases. 2:26 |
| ISSN: |
2231-0738 |
| DOI: |
10.4103/2231-0738.93129 |
| Popis: |
Aims: The aim of the present study was to quantify the changes in pharmacodynamic response during cold stimulation-induced pain. Materials and Methods: In the present study we evaluated the effect of cold stimulation (immersion of hand into cold water, 1 ± 0.5°C) in 24 healthy human subjects. Change in skin conductance (in the form of galvanic skin response), skin temperature, and heart rate were recorded using the Data Acquisition System (Biopac mp 150). Results: There was significant increase in skin conductance ( P P Conclusion: The findings of this study showed that an increase in skin conductance seemed to be a good indicator of acute pain. The changes in skin conductance were influenced by acute pain; therefore, monitoring skin conductance could be used as a pharmacodynamic parameter in the evaluation of analgesic agents. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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