Flavanones from the Twigs and Barks of Artocarpus lakoocha Having Antiplasmodial and Anti-TB Activities
| Autor: | Yongle Du, Sirada Boonyaketgoson, Kongkiat Trisuwan, Maria B. Cassera, David G. I. Kingston, Ana L. Valenciano Murillo |
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| Rok vydání: | 2020 |
| Předmět: |
biology
Traditional medicine medicine.drug_class Artocarpus lakoocha Plasmodium falciparum General Chemistry General Medicine Antimycobacterial biology.organism_classification Minimum inhibitory concentration chemistry.chemical_compound Chromatographic separation chemistry Drug Discovery medicine Ic50 values Flavanone |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 68:671-674 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.c20-00080 |
| Popis: | Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2-12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 with IC50 values of 36.7 and 33.9 µM, respectively. Moreover, moracin C (4) and sanggenofuran B (5) showed cytotoxic activity against A2780 cell line with the respective IC50 values of 15.0 and 57.1 µM. In addition, cyclocommunin (7) displayed strong antimycobacterial activity against Mycobacterium tuberculosis H37Ra with the minimum inhibitory concentration (MIC) value of 12.3 µM. |
| Databáze: | OpenAIRE |
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