| Popis: |
Ahlfors UG, Elovaara S, Harma P, Suoniemi I, Heikkila L, Nummi K, Vartiainen A, Var-tiainen H, Tarnminen T, Elgen K, Sundman K. Clinical multicentre study of citalopram compared double-blindly with mianserin in depressed patients in Finland.The aim of the trial was to study the antidepressant effect and side effects of citalopram and mianserin in a double-blind, multicentre study in six psychiatric hospitals in Finland. Patients of both sexes, aged 18 to 70 years, were included. The depression was classified as endogenous or non-endogenous by means of the Newcastle Depression Scale (1). Thirty-seven patients were allocated to treatment with citalopram and 34 to treatment with mianserin. Six patients (5+1) did not fulfil the inclusion criteria and nine patients (4+5) dropped out of the study. Citalopram. 40-60 mg daily, and mianserin, 60-90 mg daily, were given once a day in the evening for 4 weeks. The patients were assessed before treatment and after 1, 2, and 4 weeks. The Clinical Global Impression Scal... |
