Neutrophil extracellular traps-periodontal implications of netosis: A literature review

Autor:	Darshan Bm, Apoorva Sm, Divya Bhat, Suchetha A, Sapna N, Swati George
Rok vydání:	2021
Předmět:	Periodontitis Innate immune system business.industry Inflammation Neutrophil extracellular traps Disease medicine.disease Chromatin Immune system Periodontal disease Immunology Medicine medicine.symptom business
Zdroj:	International Journal of Applied Dental Sciences. 7:234-240
ISSN:	2394-7497 2394-7489
DOI:	10.22271/oral.2021.v7.i1d.1138
Popis:	Neutrophils are the primary line of innate immune defense against infectious diseases. Numerous researches in the field of neutrophil cell biology explain their role in skewing the immune response in various infections or inflammatory disorders revealed their importance within the regulation of immune response. It has been demonstrated that neutrophils release neutrophil extracellular traps (NETs) for the containment of infection and inflammation. NETosis, being an alternate style of death is that the creation of web-like chromatin decondensates by suitably primed neutrophils as a response to stimulus geared toward containing and eliminating the identical. NETs are implicated in periodontitis and COVID-19 as both these disease form a state of inflammation and be a source of constant harm to the tissues involved. This review thereby highlights the emerging role of neutrophil extracellular trap production in the regulation of immune response and its implication in periodontal disease predisposing towards adverse COVID-19 related outcomes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d7eb745f7f6107828844643e17263c3a https://doi.org/10.22271/oral.2021.v7.i1d.1138 Zobrazit plný text záznamu