Validation study of the Parkinson’s Fatigue Scale in advanced Parkinson’s disease
| Autor: | Francesc Valldeoriola, John B. Wetmore, María José Catalán, Pablo Martinez-Martin, Carmen Rodriguez-Blazquez, José Matías Arbelo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Validation study Parkinson's disease business.industry 030503 health policy & services Beck Depression Inventory Construct validity medicine.disease 03 medical and health sciences 0302 clinical medicine Cronbach's alpha 030220 oncology & carcinogenesis Internal consistency medicine Physical therapy Anxiety Apathy medicine.symptom 0305 other medical science business |
| Zdroj: | Patient Related Outcome Measures. 10:141-152 |
| ISSN: | 1179-271X |
| Popis: | Purpose: To validate the Parkinson’s Fatigue Scale (PFS-16) in advanced Parkinson Disease (APD) patients using the scale’s Spanish version. Patients and methods: In a clinical study for Levodopa-Carbidopa Intestinal Gel (LCIG), 59 patients were assessed over six months using the PFS-16 and other instruments. The psychometric properties of the PFS-16 were then analyzed. Results: Patients (60.7% men) were aged 68.02±7.43 years. PD duration was 12.57±5.97 years. Median Hoehn and Yahr (HY) stage of patients in “on” was 2 (range: 1–4). There were excellent data quality and acceptability for the PFS-16 as a whole, except for moderate-to-high ceiling effects in its items. Two factors explained 67% of the variance, yet parallel analysis demonstrated the unidimensional nature of the PFS-16, whose internal consistency was satisfactory (Cronbach’s alpha=0.93; item homogeneity coefficient=0.19, and item total-corrected correlations=0.50–0.84). PFS-16 total score showed moderate-to-high correlations with fatigue-specific questions within clinical tools, namely item 20 of the Beck Depression Inventory (rS=0.65) and item 4 of the Non-Motor Symptoms Scale (rS=0.33). Weak-to-moderate correlations were observed between the PFS-16 and measures of anxiety, depression, apathy, and quality of life. There were no significant differences in PFS-16 total scores when grouped by age, sex, time from diagnosis, HY, and CGI-S. After treatment with LCIG, the relative change in PFS-16 total score was −17.6% and the effect size (Cohen’s d) was 0.92. Moderate correlations between changes in the PFS-16 and several other clinical tools were also found. Conclusion: In APD patients, the PFS-16 showed satisfactory acceptability, internal consistency, construct validity, and responsiveness. |
| Databáze: | OpenAIRE |
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