Cytochrome B558Component of O-2MGenerating Oxidase in the Neutrophils From Patients With Chronic Granulomatous Disease

Autor:	Tooru Nakao, Naoki Takayanagi, Shunzo Chiba, Yuichi Niida
Rok vydání:	1985
Předmět:	Oxidase test NADPH oxidase biology Cytochrome Cytochrome b business.industry Flavoprotein medicine.disease Electron transport chain Molecular biology Chronic granulomatous disease Biochemistry Male patient Pediatrics Perinatology and Child Health biology.protein medicine business
Zdroj:	Pediatrics International. 27:511-515
ISSN:	1442-200X 1328-8067
DOI:	10.1111/j.1442-200x.1985.tb00673.x
Popis:	Cytochrome b558 is probably a component of an electron transport chain which is called NADPH oxidase. Cytochrome b558 from the neutrophils of two male patients with chronic granulomatous disease (CGD) and their parents was studied. One of the CGD patients had decreased amounts of cytochrome b558, The α-band of light absorption of cytochrome b558 at 558 nm was found as a trace, and the peak of the γ-band was shifted to 420 nm, whereas the normal γ-band is at 426 nm. Intermediate amounts of cytochrome b558 were present in his mother, whereas his father had a normal amount. Another patient had normal peaks of α- and γ-bands of cytochrome b558. Thus, abnormalities in NADPH oxidase of the two patients were different.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d7e950326d6fb8dbc2a36d98788218f1 https://doi.org/10.1111/j.1442-200x.1985.tb00673.x Zobrazit plný text záznamu Plný text