Validation of Unani concept of Abadāl-i-Adwiya (drug substitution) by physicochemical standardization and hepatoprotective activity of Aristolochia rotunda Linn. and its substitute Curcuma Zedoaria Rosc. in albino Wistar rats
| Autor: | N Zaheer Ahmed, Sumyyah Hasina Sana, Mohammad Younis Dar, Pankaj Goswami, Athar Parvez Ansari |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
medicine.medical_specialty biology Traditional medicine business.industry Group ii CCL4 biology.organism_classification 01 natural sciences Aristolochia rotunda Drug Substitution food.food Drug substitute 03 medical and health sciences 0302 clinical medicine food Complementary and alternative medicine Phytochemical Medicine Histopathology 030212 general & internal medicine Curcuma zedoaria business 010606 plant biology & botany |
| Zdroj: | Journal of Complementary and Integrative Medicine. 19:913-920 |
| ISSN: | 1553-3840 2194-6329 |
| Popis: | Objectives To validate the concept of abadāl-i-adwiya (drug substitution) by evaluation of physicochemical standardization and hepatoprotective activity of Aristolochia rotunda & its substitute, Curcuma Zedoaria in albino Wistar rats. Methods Physicochemical standardization by estimation of moisture content, ash values and extractive values were carried out using standard methods. Hepatotoxicity was induced in albino Wistar rats using CCl4 1 mL/kg s. c. on alternate day for 14 days. Group I was served as Plain control and Group II as Negative control. Group III was administered silymarin 50 mg/kg p. o. while Group IV received HAE of A. rotunda 89.64 mg/kg p. o., and Group V was administered HAE of C. Zedoaria 45.73 mg/kg p. o. At the end of the study, serum bilirubin, AST (SGOT), ALT (SGPT) and ALP were estimated. The histopathology of liver was also carried out. Results The physicochemical parameters of both test drugs viz. moisture content, total ash, acid insoluble ash and water soluble ash were found within normal limit. The total serum bilirubin, direct bilirubin, AST (SGOT), ALT (SGPT) levels were significantly decreased in Test groups A and B when compared to the Negative and Standard controls. The microscopic examination of liver collected from animals of Group IV and Group V revealed significant recovery from hepatic toxicity compared to the Negative control. Conclusions The study experimentation has revealed that C. Zedoaria may be used as a substitute for A. rotunda in the treatment of liver diseases. However, the outcome has to be further corroborated with phytochemical evaluation and clinical trials of both the drugs. Furthermore, the concept of drug substitute in Unani system of medicine is also validated in the light of above study. |
| Databáze: | OpenAIRE |
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