Elevated Gamma Delta T Cell Recovery Following Hematopoietic Stem Cell Transplantation Associated with Improved Long Term Overall Survival in Pediatric Patients with Acute Leukemia
| Autor: | Ross Perko, Paul G. Thomas, Mari Hashitate Dallas |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Acute leukemia medicine.medical_treatment T cell Immunology Cell Biology Hematology Hematopoietic stem cell transplantation Biology medicine.disease Biochemistry Gastroenterology Immune system Graft-versus-host disease medicine.anatomical_structure Median follow-up Internal medicine medicine Intraepithelial lymphocyte Gamma delta T cell |
| Zdroj: | Blood. 120:227-227 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v120.21.227.227 |
| Popis: | Abstract 227 Recent studies show that accelerated γΔ T cell reconstitution after hematopoietic stem cell transplantation (HSCT) is associated with improved overall survival (OS) though the mechanisms have not been elucidated. Here, we confirm that early γΔ T cell recovery after HSCT is an independent predictor for improving OS and event free survival (EFS). Moreover, patients with robust γΔ T cell recovery after HSCT appear to be protected from increased risk of serious life threatening infections, and acute gut and chronic graft versus host disease (GVHD). More importantly, we show that γΔ T cell recovery dynamics are independent from those of classical αβ T cells. We evaluated 102 consecutive pediatric patients with acute leukemia undergoing HSCT at St. Jude Children's Research Hospital from 1996–2011. The median age of the patients was 10.5 ± 5.9 yrs. (range, 0.6–25.2) and median follow up was 2.7±1.8 yrs. (range 0.2–6.0). There were 57% males, 43% females and 59% with ALL and 41% with AML. There were 14 patients with elevated γΔ T cells (≥1.75×105 cells/ml) and 88 with low/normal γΔ T cells ( Disclosures: No relevant conflicts of interest to declare. |
| Databáze: | OpenAIRE |
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