Organ-specific transcripts as a source of gene multifunctionality: lessons learned from the Drosophila melanogaster sbr (Dm nxf1) gene

Autor:	L. A. Mamon, Sergey Kliver, Mariya Toropko, E. V. Golubkova, Viktoria Ginanova
Rok vydání:	2019
Předmět:	Transcriptome Polyadenylation biology RNA editing Alternative splicing RNA splicing Melanogaster Computational biology Drosophila melanogaster General Agricultural and Biological Sciences biology.organism_classification Gene General Biochemistry Genetics and Molecular Biology
Zdroj:	Biological Communications. 64:146-157
ISSN:	2587-5779 2542-2154
DOI:	10.21638/spbu03.2019.206
Popis:	Analysis of the transcriptomes of different organisms has demonstrated that a single gene can have multiple transcripts. The sources of transcriptional variability are the alternative promoters, polyadenylation sites, splicing, and RNA editing. A comparison of the organisms of different taxa has demonstrated that the complexity of organization during evolution arises not due to an increase in the number of protein-coding genes. The greatest variability of transcripts is specific to the nervous and germinal systems. A variety of mechanisms providing for the complexity of the transcriptome ensures a precise and coordinated regulation of organ-specific functions through a combination of cis-acting elements and trans-acting factors. The D. melanogaster sbr (Dm nxf1) gene has proven to be an excellent model for investigating mechanisms potentially leading to the emergence of multiple products with various functions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d7dc51634f77afcf68cf7d46165b18f4 https://doi.org/10.21638/spbu03.2019.206 Zobrazit plný text záznamu