Changes on cerebral antioxidant enzymes, peroxidation, and the glutathione system of frogs after aging and catalase inhibition
| Autor: | Mónica López-Torres, G. Barja de Quiroga, R. Pérez-Campo |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Antioxidant biology medicine.medical_treatment Glutathione peroxidase Glutathione reductase Glutathione Metabolism Superoxide dismutase Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology chemistry In vivo Catalase Internal medicine biology.protein medicine |
| Zdroj: | Journal of Neuroscience Research. 26:370-376 |
| ISSN: | 0360-4012 |
| DOI: | 10.1002/jnr.490260314 |
| Popis: | The five major antioxidant enzymes, glutathione, and in vivo or in vitro stimulated (Fe(++)-ascorbate) peroxidation were similar in old and young Rana perezi frogs. Long-term (2.5 months) treatment with aminotriazole strongly decreased cerebral catalase (CAT) activity and increased in vivo but not in vitro peroxidation in the brain. This suggests that the increase in endogenous brain peroxidation after CAT inhibition is due to an increased free-radical attack on cerebral membranes, and not to a possible increase in their sensitivity to peroxidative damage. The increase of in vivo peroxidation is especially remarkable taking into account the low levels of CAT present in the vertebrate brain. On the other hand, these changes were not accompanied by any effect on the survival of the animals. Comparison of these results with those obtained in other species suggests the possibility that O2-free radicals be of minor importance in relation to brain aging in animals with low rates of oxygen consumption. |
| Databáze: | OpenAIRE |
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