| Autor: |
Sheri VanOmen, Kwaku Osei Bonsu, Polina Gorodinsky, Fatima Farooq, Fitz Tavernier, Cathy Segbefia, Danielle Canter, Rhonda Douglas, Austin Novarra, Brittne Halford, Rebekah Urbonya, Lewis Graham, Tulana Kpadenou, Andrew D. Campbell, Onike P Rodrigues, Marianna Yamamoto, Rachel Issaka, Clementine Fu, Fredericka Sey, Alexandra M. Sims, Duna Martin, Samuel Wilson, Charles Antwi-Boasiako |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-154883/v1 |
| Popis: |
Background: Despite having the highest prevalence of sickle cell disease (SCD), Sub-Saharan Africa lacks a robust screening program. We sought to capture the diagnosis patterns of SCD, particularly age and mechanism at SCD and age of first pain crisis, in Accra, Ghana. Methods We administered a survey to parents of offspring with SCD between 2009–2013 in Accra as a part of a larger cohort study and analyzed a subset of the data to determine diagnosis patterns. Univariate analyses were performed on diagnostic patterns; bivariate analyses were conducted to determine if patterns differ by offspring’s age, or their disease severity. Pearson’s chi-squared were calculated. Results Data was collected on 354 unique participants from parents. 44% were diagnosed with SCD by age four; 46% had experienced a pain crisis by the same age. 66% were diagnosed during pain crisis, either in acute (49%) or primary care (17%) settings. Younger ( = 18 years) group, 30% were diagnosed by four years (p p = 0.009). Conclusions These findings reflect a reliance on diagnosis in acute settings, and a relative underutilization of systematic screening programs. By understanding current patterns, opportunities remain to more effectively detect and treat SCD in this high prevalence population. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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