CD177 Expression on Neutrophils
| Autor: | Alison Edinger, Ebenezer S. Osei, Karen Schweitzer, Howard J. Meyerson, Anna Balog, Georgetta Blidaru |
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| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | American Journal of Clinical Pathology. 140:658-669 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1309/ajcpdfbebqzw1oi7 |
| Popis: | Objectives: To determine whether the fraction of CD177+ neutrophils might be altered in clonal myeloid disorders, similar to the skewed κ/λ ratio for B-cell lymphomas, and could be used to identify myeloid neoplasms. Methods: Blood and bone marrow samples were evaluated for the fraction of CD177+ neutrophils by flow cytometry. Results: Skewed high neutrophil CD177(%) was not associated with neoplasia, but skewed low neutrophil CD177(%) was highly correlated with clonal myeloid disorders at values less than 40%. Specificity of low neutrophil CD177(%) for clonal myeloid disorders was 87% with a 40% cutoff and 95% with a 30% cutoff. Findings were most pronounced for myelodysplasia, with 52% (11/21) containing fewer than 40% CD177+ neutrophils. Specificity was also suggested by normalization of neutrophil CD177(%) in four patients who reached morphologic remission after therapy for myelodysplasia or acute leukemia. Conclusions: Skewed low neutrophil CD177(%) is highly associated with clonal myeloid disorders, particularly myelodysplasia, and may be useful for detecting clonal myeloid disorders. |
| Databáze: | OpenAIRE |
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