| Autor: |
Vimal Arora, Rajiv Sharma, Saahil Arora, A. Kapila, R.B. Sharma |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Materials Today: Proceedings. 48:1638-1644 |
| ISSN: |
2214-7853 |
| DOI: |
10.1016/j.matpr.2021.09.526 |
| Popis: |
The aim of this study to find out the role of biomaterial cross carmellose sodium and Eudragit s100 is to control the drug release drug dosage form into a particular site, colon, which is part of large intestine. The drug Budesonide was used as a model drug. In this study nine formulations (F1-F9) were prepared using different concentration of polymer, cross carmellose Sodium and all were evaluated as per standard parameters, and found as per prescribed standards. All formulation were pursued for coating process using Eudragit S100 as a polymer and different excipients like castor oil act as a plasticizer, talc as anti-agglomerative agent. All the formulation showed significant role in gastric media, i.e. 0.1 NHCl does not release the drug in in GI fluids for 2 h. Most of the formulation has given their release above 90% but F4 has given its release 99.4 in 36 h in colon part of large intestine. It shows a sustained and constant release performance till next 36 h which showing the best release among all formulation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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