Preparations of antifungal Sch 42427/SM 9164: Preparative chromatographic resolution, and total asymmetric synthesis via enzymatic preparation of chiral α-hydroxy arylketones

Autor:	Bruce L. Murphy, M. Steinman, D. Gala, Doris P. Schumacher, Donald J. Dibenedetto, Clark Jon E
Rok vydání:	1996
Předmět:	chemistry.chemical_classification Antifungal Resolution (mass spectrometry) medicine.drug_class Organic Chemistry Enantioselective synthesis Biochemistry Combinatorial chemistry Chromatographic separation Enzyme chemistry Drug Discovery medicine Azole Enantiomer
Zdroj:	Tetrahedron Letters. 37:611-614
ISSN:	0040-4039
DOI:	10.1016/0040-4039(95)02234-1
Popis:	Efficient approaches towards the preparation of chiral azole antifungals Sch 42427/SM 9164 (1) via large scale chromatographic separation of its enantiomers, or via enzymatic syntheses of key chiral intermediates α-hydroxy arylketones 5 in excellent enantiomeric excesses (ees) are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d7bdaa9152421b1a7733725cf7232ecc https://doi.org/10.1016/0040-4039(95)02234-1 Zobrazit plný text záznamu Full Text from ScienceDirect