Continuation of clozapine treatment: practice makes perfect
| Autor: | Denise Duncan-McConnell, Til Wykes, Eromona Whiskey, Elke Haworth, Nicholas D. Walsh, Sarah Hastilow |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
business.industry Neutropenia medicine.disease 030227 psychiatry 03 medical and health sciences Psychiatry and Mental health Continuation 0302 clinical medicine Older patients Treatment practice medicine 030212 general & internal medicine Intensive care medicine Psychiatry business Clozapine medicine.drug |
| Zdroj: | Psychiatric Bulletin. 27:211-213 |
| ISSN: | 1472-1473 0955-6036 |
| DOI: | 10.1192/pb.27.6.211 |
| Popis: | Aims and MethodThe study aimed to identify the predictors of drop-out from clozapine treatment by examining the demographic and clinical characteristics of patients registered on clozapine within a 6-month period in one NHS Trust.ResultsDuring the study period, 54 patients were registered and began clozapine treatment and 31% had discontinued within 6 months. Two people died and the remainder discontinued because of non-compliance or side-effects, including neutropenia. Two factors were predictive: the age of the patient (older patients were more likely to discontinue) and the hospital where the initial registration was made.Clinical ImplicationsNeither ethnicity, previous registration nor the individual prescriber are a bar to successful persistence with clozapine. However, one set of hospitals with a history of evidence-based practice and high clozapine prescribing was more successful in retaining patients on maintenance treatment. Although specific data are needed to identify more subtle contributing factors to continuation, it is clear that there is scope for improving the rate of persistence with clozapine treatment. |
| Databáze: | OpenAIRE |
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