The Usefulness of the Nude Mouse Model for Predicting the Chemosensitivity of Human Tumors. Studies in Malignant Melanoma
| Autor: | S. Aamdal, A. Pihl, Ø. Fodstad |
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| Rok vydání: | 1988 |
| Předmět: |
Drug
Chemotherapy Pathology medicine.medical_specialty biology business.industry medicine.medical_treatment Melanoma media_common.quotation_subject Cancer medicine.disease biology.organism_classification Vinblastine Nude mouse Preclinical phase Cancer research Medicine business Chemosensitivity assay medicine.drug media_common |
| Zdroj: | Human Tumour Xenografts in Anticancer Drug Development ISBN: 9783642732546 |
| Popis: | The usefulness of human tumor xenografts in ex perimental chemotherapy depends on the representativity of the xenografts used for the respective types of clinical cancer. The overall experience in malignant melanoma has provided strong evidence in support of the validity of the nude mouse xenograft system for chemosensitivity testing. A sensitivity profile obtained in a panel of 5 melanoma xenografts seemed to reflect the clinical situation, and a pattern of tumor response to CCNU and vinblastine similar to that seen in the clinic was reproduced in xenografts. Moreover, a clear relationship between tumor size and response to vinblastine was demonstrated. In screening new drugs, shortterm assays may be useful as prescreens, but the need for long-term experiments in nude mice is emphasized. A new drug, Mitozolomide, was selected in preclinical Phase II studies in xenografts for evaluation in melanoma patients, and since clinical activity of this drug was later established, the results support a more extended use of this approach. Furthermore, it is proposed that analogs of established drugs should undergo careful preclinical selection before being introduced in the clinic. |
| Databáze: | OpenAIRE |
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