Synthesis and Hypotensive Activity of Novel Styryl Derivatives Based on Ethyl-4-(4-Methoxyphenyl)-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
| Autor: | S. D. Fazylov, A. N. Zhakupova, A. E. Arinova, T. S. Zhivotova, O. A. Nurkenov, I. S. Tolepbek, L. E. Muravleva, R. E. Bakirova |
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| Rok vydání: | 2016 |
| Předmět: |
Pharmacology
010405 organic chemistry Stereochemistry Biginelli reaction Acetoacetic ester synthesis Pharmacology toxicology 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Thiourea Yield (chemistry) Drug Discovery Carboxylate |
| Zdroj: | Pharmaceutical Chemistry Journal. 50:440-442 |
| ISSN: | 1573-9031 0091-150X |
| DOI: | 10.1007/s11094-016-1466-2 |
| Popis: | Three-component condensation of thiourea, ethyl acetoacetic ester, and anisaldehyde was performed to synthesize ethyl-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate. This compound interacted with aromatic aldehydes to yield the corresponding styryl derivatives. The hypotensive activity of the compounds synthesized here was assessed. |
| Databáze: | OpenAIRE |
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