1225 Ondansetron (OND) vs granisetron (GRA) in the control of chemotherapy-induced acute emesis

Autor: Vincenzo Adamo, I. Carreca, V. Leonardi, S. Vitello, M. Cammarata, F. Pagliarello, S. Palmeri, E. Ianniuo, G. Failla, Giuseppe Altavilla, A. Di Carlo, R. Carroccio, C. Iacono, R. Aiello, G. Tarantino
Rok vydání: 1995
Předmět:
Zdroj: European Journal of Cancer. 31:S256
ISSN: 0959-8049
Popis: Nausea and Vomiting (N/V) are very frequent side effects of cancer chemotherapy. 5HT3 receptors antagonists are new antiemetic drugs that can improve quality of life of cancer patients receiving chemotherapy. We have conducted a multicentric randomized study to compare the efficacy and tolerability of two 5HT3 receptors antagonist: OND and GRA. We enrolled 118 non-pretreated cancer pts (70 females, 48 males) to receive OND 0.15 mg/kg iv dl (repeated at 2 and 4 hrs) (116 cycles) or GRA 40 mcr/kg iv dl (117 cycles) before chemotherapy regimen. Each pt was randomized to receive one of two schedules at first cycle and the other schedule at second cycle. The main patient characteristics were: mean age 51 yrs, KI 0–3.48 (41%) pts received highly emetogenic chemotherapy (HE), 70 (59%) pts received moderate emetogenic chemotherapy (ME). Thirty-six per cent of pts had breast cancer, 24% lung, 16% LH/LNH, 24% other. Of the total 233 cycles administered (93 HE, 140ME) we have registered the following results: (1) HE regimen: N/V grade (G)1 11% (OND) and 11% (GRA), G2 17% (OND) and 17% (GRA), G3 4% (OND) and 2% (GRA). Seventeen per cent (OND) and 20% (GRA) had not N/Y. (2) ME regimen: N/V grade (G) 1 16% (OND) and 16% (GRA), G2 15% (OND) and 11% (GRA), G3 2% (OND) and 3% (GRA). Seventeen per cent (OND) and 21% (GRA) had not N/V. The main toxicities were: headache 24% (OND) and 23% (GRA), light-headedness 13% (OND) and 18% (GRA), constipation 11% (OND) and 6% (GRA), other 6% (OND) and 6% (GRA). None of these differences were statistically significant. It is to note that each pt was requested to express a preference between the two drugs: 22% of pts chose OND, 38% GRA and 40% expressed no preference. These differences are statistically significant (α = 0.05). In conclusion we think that OND and GRA are effective but the two drugs are equally active and toxic. From a subjective point of view we noted a trend in favour of GRA.
Databáze: OpenAIRE
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