Comparative Modeling of Drug Target Proteins☆

Autor: Andrej Sali, U. Pieper, H. Fan, Ben Webb, Narayanan Eswar, G.Q. Dong, Natalia Khuri
Rok vydání: 2014
Předmět:
DOI: 10.1016/b978-0-12-409547-2.11133-3
Popis: In this perspective, we begin by describing the comparative protein structure modeling technique and the accuracy of the corresponding models. We then discuss the significant role that comparative prediction plays in drug discovery. We focus on virtual ligand screening against comparative models and illustrate the state-of-the-art by a number of specific examples.
Databáze: OpenAIRE