Application of Molecular Adsorbents Recirculating System to remove NO and cytokines in severe liver failure patients with multiple organ dysfunction syndrome
| Autor: | Xia Guo, Hong-yu Zhang, Min-min Wang, Dao-zhen Xu, Li-min Guo, Jian-ping Zhang, Wei-yan Zhang, Lian-he Lu, Feng-xia Sun, Bao-shun Li, Ling-hang Wang, Xiao-dong Liu, Zhong-ping He, Jing-yuan Liu, Yun Yao, Hao Han |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Hepatology business.industry medicine.medical_treatment Albumin Hemodynamics Liver transplantation medicine.disease Gastroenterology Surgery Cytokine Internal medicine Severity of illness medicine Respiratory function Multiple organ dysfunction syndrome business Hepatic encephalopathy |
| Zdroj: | Liver International. 23:16-20 |
| ISSN: | 1478-3223 |
| DOI: | 10.1034/j.1478-3231.23.s.3.7.x |
| Popis: | Background: Molecular Adsorbents Recirculating System (MARS) is a new promising artificial liver support therapy, the aim of this study was to assess the effectiveness of MARS to remove nitrous oxide (NO) and cytokines insevere liver failure patients with multiple organ dysfunction syndrome (MODS). Methods: Sixty single MARS treatments were performed with length of 6-24h on 24 severe liver failure patients (18 males/6 females) with MODS. Results: The MARS therapy was associated with a significant removal of NO and certain cytokines such as TNF-a, IL-6, IL-8, and INF-γ, together with marked reduction of other non-water-soluble albumin bound toxins and watersoluble toxins, these were associated with a improvement of the patients' clinical conditions including hepatic encephalopathy, deranged hemodynamic situation and as well as renal and respiratory function, thus resulted into marked decrease of Sequential Organ Failure Assessment (SOFA) score and improved outcome: nine patients were able to be discharged from the hospital or bridged to successful liver transplantation, the overall survival of 24 patients was 37.5%. Conclusion: We can confirm the positive therapeutic impact and safety to use MARS on liver failure patients with MODS associated with elevated levels of NO and cytokines. |
| Databáze: | OpenAIRE |
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