Prediction of progression of interstitial lung disease in patients with systemic sclerosis: the SPAR model
| Autor: | Yannick Allanore, Anna-Maria Hoffmann-Vold, Suzana Jordan, Wanlong Wu, Elise Siegert, Britta Maurer, Håvard Fretheim, Oliver Distler, Mike O Becker, Shuang Ye, Rucsandra Dobrota |
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| Rok vydání: | 2018 |
| Předmět: |
030203 arthritis & rheumatology
Vital capacity medicine.medical_specialty Receiver operating characteristic business.industry Immunology Interstitial lung disease medicine.disease General Biochemistry Genetics and Molecular Biology Pulmonary function testing 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine 030228 respiratory system Rheumatology Diffusing capacity Internal medicine Cohort Immunology and Allergy Medicine Clinical significance business |
| Zdroj: | Annals of the Rheumatic Diseases. 77:1326-1332 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2018-213201 |
| Popis: | ObjectivesTo identify the predictive clinical characteristics and establish a prediction model for the progression of mild interstitial lung disease (ILD) in patients with systemic sclerosis (SSc).MethodsPatients with SSc from two independent prospective cohorts were included in this observational study. All patients fulfilled the 2013 American College of Rheumatology/European League Against Rheumatism criteria, had mild ILD at baseline diagnosed by High-Resolution Computed Tomography (HRCT), available baseline and ≥1 annual follow-up pulmonary function tests and no concomitant pulmonary hypertension or airflow obstruction. ILD progression was defined as a relative decrease in forced vital capacity (FVC)%≥15%, or FVC%≥10% combined with diffusing capacity for carbon monoxide %≥15% at 1-year follow-up. Candidate predictors for multivariate logistic regression were selected by expert opinion based on clinical significance. A prediction model for ILD progression was established in the derivation cohort and validated in the multinational validation cohort.ResultsA total of 25/98 and 25/117 patients with SSc showed ILD progression in the derivation cohort and the validation cohort, respectively. Lower SpO2 after 6 min walk test (6MWT) and arthritis ever were identified as independent predictors for ILD progression in both cohorts. The optimal cut-off value of SpO2 after 6MWT for predicting ILD progression was determined as 94% by receiver operating characteristic curve analysis. The derived SPAR model combining both predictors (SPO2 and ARthritis) increased the prediction rate from 25.5% to 91.7% with an area under the curve (95% CI) of 0.83 (0.73 to 0.93).ConclusionsThe evidence-based SPAR prediction model developed in our study might be helpful for the risk stratification of patients with mild SSc-ILD in clinical practice and cohort enrichment for future clinical trial design. |
| Databáze: | OpenAIRE |
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