ChemInform Abstract: KINETICS AND MECHANISM OF THE DECOMPOSITION OF N,N-DIHALOPEPTIDES

Autor:	William D. Stanbro, Michael J. Lenkevich
Rok vydání:	1985
Předmět:	chemistry.chemical_compound Ammonia Hydrolysis Reaction rate constant Nitrile chemistry Kinetics Polymer chemistry Halide General Medicine Tripeptide Decomposition
Zdroj:	Chemischer Informationsdienst. 16
ISSN:	0009-2975
DOI:	10.1002/chin.198537109
Popis:	The tripeptide alanylalanylalanine reacts with either HOCl or HOBr to form a N,N-dihalopeptide. These compounds decompose to the N-halo-N′-(α-iminoketo)peptides plus halide ion. The rate constants for these reactions in 0.4-M NaCl were determined to be where the activation energies are in cal/mol. The N-halo-N′-(α-iminoketo)-peptides slowly decompose either by a two-step hydrolysis reaction to form ammonia, halide ion, and an N-(α-acylketo)peptide, or by direct decomposition to a nitrile, an isocyanopeptide, and a halide ion.
Databáze:	OpenAIRE
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