Heterocyclization of 1-aryl/alkyl-2-thiobiureas to 4-aryl/alkyl-3-substituted-Δ 2 -1,2,4-triazolin-5-ones

Autor:	Vipin A. Nair, C. P. Joshua, M. M. Suni
Rok vydání:	2001
Předmět:	chemistry.chemical_classification Aryl Organic Chemistry Halide Biochemistry Medicinal chemistry chemistry.chemical_compound chemistry Nucleophile Acid catalyzed Drug Discovery X-ray crystallography lipids (amino acids peptides and proteins) Alkyl
Zdroj:	Tetrahedron. 57:2003-2009
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(01)00018-7
Popis:	Synthesis of a range of 1,2,4-triazolin-5-ones has been carried out by thermally induced cyclization of 1-aryl/alkyl-2-alkyl isothiobiureas 4. The required isothiobiureas were generated in situ by the reaction of alkyl halides with 1-aryl/alkyl-2-thiobiureas 3 in acidic medium at reflux. The reaction proceeds after S-alkylation of the thiobiureas and is demonstrated by the isolation of the alkyl isothiobiurea intermediates and their subsequent acid catalyzed thermal cyclization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d7705102c4d86e4b0f40dc203a1141be https://doi.org/10.1016/s0040-4020(01)00018-7 Zobrazit plný text záznamu Full Text from ScienceDirect