Resection margins of 2 versus 5 cm for cutaneous malignant melanoma with a tumor thickness of 0.8 to 2.0 mm: A randomized study by the Swedish Melanoma Study Group

Autor: Ulrik Ringborg, Ronny Andersson, Jan Eldh, Barbro Glaumann, Larsolof Hafström, Sten Jacobsson, Per-Ebbe Jönsson, Hemming Johansson, Lennart Krysander, Bengt Lagerlöf, null Swedish Melanoma Study Group
Rok vydání: 1996
Předmět:
Zdroj: Cancer. 77:1809-1814
ISSN: 1097-0142
0008-543X
DOI: 10.1002/(sici)1097-0142(19960501)77:9<1809::aid-cncr8>3.0.co;2-6
Popis: BACKGROUND The traditional surgical treatment for primary malignant melanoma has often been a wide excision with a margin of about 5 cm. Since the risk of local recurrences is dependent on tumor thickness, thin tumors ( 0.8 and; cc 2.0 mm. The trial includes 769 patients. Patients with melanomas of the skin of the head, neck, hands, feet, or vulva were not included in the trial. In the event of an excision biopsy for diagnosis, radical surgery was completed within 6 weeks. The median follow-up time was 5.8 years for estimation of survival and 4.0 years for diagnosis of recurrent disease. RESULTS No significant differences have been observed between the treatment groups regarding local or regional recurrences or survival. CONCLUSIONS We recommend an excision with a margin of 2 cm for cutaneous malignant melanoma with a tumor thickness > 0.8 and; cc 2.0 mm. Cancer 1996;77:1809-14.
Databáze: OpenAIRE
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