| Autor: |
Amilton Paulo Raposo Costa, Jamylla Mirck Guerra de Oliveira, P. A. B. Sales, Silvana Maria Medeiros de Sousa Silva, Paulo Humberto Moreira Nunes, Tatiane Novaes Costa, lho Sa, Marina Rebeca Soares Carneiro de Sousa, Melka Coecirc |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
African Journal of Pharmacy and Pharmacology. 7:2680-2685 |
| ISSN: |
1996-0816 |
| Popis: |
Terminalia fagifolia Mart & Zucc is a typical plant from Brazilian savanna, whose stem bark is used in popular medicine for relief of gastrointestinal discomfort. A phytochemical study showed the presence of large amounts of antioxidants (flavonoids and triterpenes). In acute toxicity tests, five groups of female mice were orally treated with stem bark extract from T. fagifolia or fractions by gavage at doses 2 g/kg/day (n = 5) and general behavior, adverse effects and mortality were recorded for up to 14 days. In sub-acute toxicity assays, animals received T. fagifolia ethanol extract or fractions at doses of 80, 240 or 720 mg/kg/day (n = 6) for 30 days and biochemical and morphological parameters were determined. The acute treatment in mice produced 40% of death. The estimate for the median lethal oral dose was 2 g/kg (LD50 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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