| Popis: |
Background: In patients with cardiovascular disease candidate for angiography, one of the major concerns is the incidence of contrast-induced nephropathy (CIN), especially in patients with renal failure. The purpose of the present study was to compare the preventive effects of nicorandil and atorvastatin on the incidence of CIN in patients with chronic kidney disease (CKD). Methods: In a clinical trial study, 270 patients with renal insufficiency nominated for angiography were randomly divided into three groups (each group n=90): hydration group (1000 mL saline), hydration + atorvastatin group (80 mg/day for 3 days), and hydration + nicorandil group (10 mg 3 times/day for 3 days). Serum creatinine (Cr) and blood urea nitrogen (BUN) levels as well as glomerular filtration rate (GFR) were evaluated before and 72 hours after the intervention. Results: At the end of the study, serum Cr and BUN levels in all three groups showed a significant increase compared to the pre-intervention, which was significantly more in the control group than the two groups. Furthermore, the amount of GFR in all three groups showed a significant decrease after-intervention, which was significantly more pronounced in the control group than in both groups. No significant differences were found between nicorandil and atorvastatin in serum concentrations of Cr and BUN as well as GFR levels at the end of the study. Conclusion: The nicorandil and atorvastatin intervention showed preventive effects on CIN in CKD patient’s candidate for angiography, but there was no significant difference between the two drugs. |
