Anxiolytic potential of astaxanthin on experimental animal model
| Autor: | Vijay Yadav, Rajnish Kumar Sankadia, Rekha Mehani |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Elevated plus maze Antioxidant medicine.drug_class medicine.medical_treatment Pharmacology medicine.disease_cause Anxiolytic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Astaxanthin medicine Carotenoid chemistry.chemical_classification business.industry 030104 developmental biology chemistry Biochemistry Anxiety medicine.symptom business Diazepam 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | International Journal of Basic and Clinical Pharmacology. :131-134 |
| ISSN: | 2319-2003 |
| Popis: | Background: Astaxanthin is a naturally occurring carotenoid found in nature primarily in marine organisms. Carotenoids are well known for their therapeutic benefits in the aging process and various diseases, because of their antioxidant properties. Additionally, astaxanthin has well-documented anti-inflammatory and immune-stimulating effects. It is a known fact that oxidative stress is associated with depression, anxiety, and related psychiatric disorders. Astaxanthin may also reduce oxidative stress in the nervous system, reducing the risk of neurodegenerative diseases. Although astaxanthin has the ability to cross the blood–brain barrier and has a beneficial effect on the CNS, the effects of astaxanthin on anxiety and depression have not been reported. Methods: In this study, to investigate the effects of astaxanthin on anxiety, we performed some behavioural tests including elevated plus maze test, hole-board test, light/dark exploration test. Results: In elevated plus maze test the time spent in the closed arm by astaxanthin treated rats was significantly (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|