Pulmonary anthracosis mimicking lung metastases in pediatric rhabdomyosarcoma
| Autor: | Gabrielle Karpinsky, Aleksandra Fatyga, Dagmara Szmyd, Monika Luboch-Furmanczyk, Mirosława Dubaniewicz-Wybieralska, Ewa Bien, Malgorzata Krawczyk, Ewa Izycka-Swieszewska |
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| Rok vydání: | 2016 |
| Předmět: |
Anthracosis
Pathology medicine.medical_specialty Lung medicine.diagnostic_test business.industry respiratory system medicine.disease Primary tumor Pediatric cancer Lesion 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030228 respiratory system 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Thoracoscopy medicine Histopathology Embryonal rhabdomyosarcoma medicine.symptom business |
| Zdroj: | Pediatrics International. 58:1066-1068 |
| ISSN: | 1328-8067 |
| DOI: | 10.1111/ped.13058 |
| Popis: | Although childhood rhabdomyosarcoma typically metastasizes to lungs, various processes may mimic metastatic etiology. Described herein is the case of an 8½-year-old boy with orbital embryonal rhabdomyosarcoma (RME) in whom three small foci were detected within both lungs on computed tomography. The lesion number and size, however, did not fulfil the Cooperative Weichteilsarkom Study Group 2006 protocol criteria for lung metastasis. Chemotherapy for localized RME produced primary tumor regression and vanishing of the left lung lesion. Two lesions in the right lung remained unchanged. On thoracoscopy multiple minute nodules disseminated in both lungs were detected. Histopathology excluded RME spread but indicated anthracosis in the lung parenchyma and intrapulmonary lymph nodes. Heavy smoking by parents and previous home furnace combustion appeared to be predisposing factors. Uncommon non-malignant intrapulmonary diseases, including anthracosis, should be considered when staging pediatric cancer. |
| Databáze: | OpenAIRE |
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