Abstract 2805: A pooled investigation of circulating 25-hydroxyvitamin D and non-Hodgkin lymphoma: The Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Autor: Demetrius Albanes, Yong Bing Zhang, Richard B. Hayes, Mark P. Purdue, D. Michal Freedman, Susan M. Gapstur, Kai Yu, Judith A. Hoffman Bolton, Edward Giovannucci, Alan A. Arslan, Stephanie J. Weinstein, Kimberly A. Bertrand, Laurence N. Kolonel, Walter C. Willett, Francine Laden, Lonn Irish, Kirk Snyder, Anne Zeleniuch-Jacquotte, Wei Zheng, Patricia Hartge, Unhee Lim, Kathy J. Helzlsouer, Nathaniel Rothman, Ronald L. Horst, Gertraud Maskarinec, Victoria L. Stevens, Xiao-Ou Shu
Rok vydání: 2010
Předmět:
Zdroj: Cancer Research. 70:2805-2805
ISSN: 1538-7445
0008-5472
Popis: Findings from several epidemiologic studies suggest that exposure to solar ultraviolet radiation may be associated with a reduced risk of non-Hodgkin lymphoma (NHL). These observations have led to speculation that vitamin D may protect against lymphomagenesis. To investigate this hypothesis, the authors conducted a pooled investigation of circulating 25-hydroxyvitamin D [25(OH)D] and subsequent NHL risk within ten cohorts participating in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Prediagnostic samples of serum or plasma from 1,353 cases and 1,778 controls were assayed for 25(OH)D by immunoassay at a single laboratory. Odds ratios (ORs) and 95% confidence intervals (CIs) relating categories of 25(OH)D concentration with NHL risk were calculated using conditional logistic regression models, with 50- Overall, no evidence of association with NHL risk was observed for either low 25(OH)D concentration ( Analyses of other measures of 25(OH)D {continuous log[25(OH)D], categories of 25(OH)D using sex/cohort/season-specific cutpoints, categories of season-adjusted residuals of predicted 25(OH)D} were similarly null, as were results from stratified analyses and investigations of histologic subtypes of NHL. These findings do not support the hypothesis that elevated circulating 25(OH)D levels are associated with reduced NHL risk. Future research investigating the biologic basis for the sunlight-NHL association should consider alternative mechanisms, such as immunologic effects. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2805.
Databáze: OpenAIRE
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