| Autor: |
Chunfang Zhu, Siri H Strand, Daisy Yi Ding, Kristalyn K. Gallagher, Jose A. Seoane, Lunden A Simpson, Luis Cisneros, Allison Hall, Kornelia Polyak, Belén Rivero-Gutiérrez, Sucheta Srivastava, Kathleen E. Houlahan, Shirley Zhu, Cody Straub, Aziz Khan, Dadong Zhang, Magdalena Matusiak, Deborah J. Veis, Alastair M. Thompson, Mark R. Kilgore, Julie R. Nangia, Jeffrey R. Marks, Jennifer F. Tseng, Robert B. West, Timothy Hardman, Angela DeMichele, Graham A. Colditz, Anna Maria Storniolo, Tari King, Kouros Owzar, Jen Tappenden, E. Shelley Hwang, Robert M. Angelo, Joanna Lee, Shu Jiang, Sushama Varma, Carlo C. Maley, Priscilla F. McAuliffe, Lauren Anderson, Shi Wei, Katherine DeSchryver, Robert Tibshirani, Robyn Burns, Gaorav P. Gupta, Sujay Vennam, Bryan Harmon, Lorraine M. King, Christina Curtis, Jason K. Wang, Jingqin Luo, Tyler Risom, Fergus J. Couch |
| Rok vydání: |
2021 |
| Předmět: |
|
| DOI: |
10.1101/2021.06.16.448585 |
| Popis: |
SUMMARYDuctal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We have performed the first multiscale, integrated profiling of DCIS with clinical outcomes by analyzing 677 DCIS samples from 481 patients with 7.1 years median follow-up from the Translational Breast Cancer Research Consortium (TBCRC) 038 study and the Resource of Archival Breast Tissue (RAHBT) cohorts. We identified 812 genes associated with ipsilateral recurrence within 5 years from treatment and developed a classifier that was predictive of DCIS or IBC recurrence in both cohorts. Pathways associated with recurrence include proliferation, immune response, and metabolism. Distinct stromal expression patterns and immune cell compositions were identified. Our multiscale approach employed in situ methods to generate a spatially resolved atlas of breast precancers, where complementary modalities can be directly compared and correlated with conventional pathology findings, disease states, and clinical outcome.HIGHLIGHTS⍰ Development of a new classifier for DCIS recurrence or progression⍰ Outcome associated pathways identified across multiple data types and compartments⍰ Four stroma-specific signatures identified⍰ CNAs characterize DCIS subgroups associated with high risk invasive cancers |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
