The influence of an IL-4 variable number tandem repeat (VNTR) polymorphism on breast cancer susceptibility
| Autor: | Doaa M Rababa'h, Laith N. AL-Eitan, Mansour A. Alghamdi, Rame Khasawneh |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pharmacology Oncology medicine.medical_specialty business.industry medicine.disease Malignancy 03 medical and health sciences Variable number tandem repeat 030104 developmental biology 0302 clinical medicine Breast cancer 030220 oncology & carcinogenesis Internal medicine Genotype Genetic variation Etiology Molecular Medicine Medicine business Body mass index Gene |
| Zdroj: | Pharmacogenomics and Personalized Medicine. 12:201-207 |
| ISSN: | 1178-7066 |
| DOI: | 10.2147/pgpm.s220571 |
| Popis: | Backgrounds Breast cancer (BC) is one of the most widespread cancers globally. Understanding the etiology of BC may help in determining the various risk factors involved in its malignancy. Certain genetic mutations are considered to play a key role in increasing the risk of BC. Objectives In this study, we explored the correlation between a variable number tandem repeat (VNTR) polymorphism in the IL-4 gene and BC. Methods PCR and subsequent gel electrophoresis were used to genotype this variant in 360 Jordanian women (180 BC patients and 180 controls). In addition, phenotype-genotype analysis was carried out. Results Our findings illustrate that there is no significant relationship between the variant genotypes in the IL-4 gene and BC among Jordanian females. Other than body mass index and tumor differentiation (p< 0.05), none of the clinical and pathological parameters of BC patients exhibited any association with the variant genotypes. Conclusions From this study, we propose that the IL-4 genetic variant does not impact BC development and progression but that it could influence the disease prognosis. |
| Databáze: | OpenAIRE |
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