CYP3A5 and PPARA genetic variants are associated with low trough concentration to dose ratio of tacrolimus in kidney transplant recipients
| Autor: | Fernando José Brito Patrício, Elen Almeida Romão, Teresa Cristina Alves Ferreira, Manuel dos Santos Faria, Gyl Eanes Barros Silva, Janaína B. F. Everton, Marcelo Magalhães |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
education.field_of_study medicine.medical_specialty business.industry Population General Medicine medicine.disease 030226 pharmacology & pharmacy Gastroenterology Tacrolimus 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Internal medicine Genotype Medicine Pharmacology (medical) 030212 general & internal medicine Allele business education CYP3A5 Genotyping Kidney transplantation |
| Zdroj: | European Journal of Clinical Pharmacology. 77:879-886 |
| ISSN: | 1432-1041 0031-6970 |
| Popis: | Genetic polymorphisms have been associated with variation in the metabolism of tacrolimus (TAC) in kidney transplant patients. This study is aimed at assessing the impact of allelic variants of CYP3A5 and PPARA genes on the pharmacokinetics (PK) of TAC in Brazilian kidney transplant recipients in the first-year post-transplant. A total of 127 patients were included for genetic evaluation. Genomic DNA was isolated from peripheral blood and real-time PCR was used to analyze the main polymorphisms described for the genes CYP3A5 (rs776746; C > G) and PPARA (rs4823613; A > G and rs4253728; G > A). CYP3A5 expressors showed a lower Co/dose ratio than non-expressors, with the median values of this parameter |
| Databáze: | OpenAIRE |
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