ACTIVITY OF MITOCHONDRIAL ANTIOXIDANT DEFENSE SYSTEM IN YOUNG PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE
| Autor: | Tamara Pasiieshvili, Olga Kovalyova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Antioxidant business.industry medicine.medical_treatment Reflux Disease medicine.disease Gastroenterology Pathogenesis 03 medical and health sciences 0302 clinical medicine Blood serum medicine.anatomical_structure 030220 oncology & carcinogenesis Internal medicine medicine GERD Biomarker (medicine) 030211 gastroenterology & hepatology Esophagus business |
| Zdroj: | Inter Collegas. 7:164-167 |
| ISSN: | 2409-9988 |
| DOI: | 10.35339/ic.7.4.164-167 |
| Popis: | Background. Despite numerous studies, the pathogenesis of gastroesophageal reflux disease remains unclear. Aim of research: assessment the activity of antioxidant defense system in young patients with GERD based on expression of biomarker associated with mitochondrial function. Material and methods. The study included 45 patients with gastroesophageal reflux disease. The examined contingent was presented by students age from 18 to 25 years. 20 healthy persons were included as control group. Levels of manganese superoxide dismutase were determined in blood serum of study persons with enzyme immunoassays (ELISA, Elabscience, USA). Statistical data processing by the Statistica Basic Academic 13 for Windows En local was made. Results. Gastroesophageal reflux disease in young patients is characterized by significantly increasing of manganese superoxide dismutase as compare to control group (7.1700 ng/ml vs 4.4720 ng/ml respectively, p |
| Databáze: | OpenAIRE |
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