Concentration of putrescine in plasma, frontal cortex and hippocampus of rats after systemic administration of the convulsants N-methyl-d-aspartate, pentylentetrazol, picrotoxinine, lindane and 4-aminpyridine

Autor:	Emili Martínez, L. Gimenez-Llort, L. Camón, N. De Vera
Rok vydání:	1996
Předmět:	medicine.medical_specialty General Neuroscience Central nervous system Hippocampus Convulsants Ornithine decarboxylase chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine Convulsion Putrescine medicine NMDA receptor medicine.symptom Polyamine
Zdroj:	Neuroscience Letters. 217:1-4
ISSN:	0304-3940
DOI:	10.1016/0304-3940(96)13073-1
Popis:	The motor responses (such as stereotypic behavior or convulsions) induced in rats by N-methyl- d -aspartate (NMDA) administered systemically were followed by a rapid, moderate increase in the putrescine concentration in plasma which preceded an increase in this amine in the brain. This effect was not observed following the convulsions evoked by pentylentetrazol, picrotoxinine, lindane or 4-aminopyridine. However, all the convulsants assayed induced a mild increase in the concentration of putrescine in the frontal cortex and hippocampus. A differential activation of the ornithine decarboxylase (ODC)/polyamine system in both cerebral and peripheral tissues could account for these results.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d7500f24dc82aa98b4eb327e8cfb57f1 https://doi.org/10.1016/0304-3940(96)13073-1 Zobrazit plný text záznamu Full Text from ScienceDirect