C–H 18F-fluorination of 8-methylquinolines with Ag[18F]F
| Autor: | Allen F. Brooks, So Jeong Lee, Katarina J. Makaravage, Peter J. H. Scott, Melanie S. Sanford, Andrew V. Mossine, Naoko Ichiishi |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
010405 organic chemistry Metals and Alloys General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Fully automated Materials Chemistry Ceramics and Composites |
| Zdroj: | Chemical Communications. 55:2976-2979 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | This report describes a Pd-mediated C–H radiofluorination of 8-methylquinoline derivatives with no-carrier-added Ag[18F]F. To achieve this transformation, a new method was developed for the generation of Ag[18F]F using a sep-pak cartridge. The C–H radiofluorination was then optimized and applied to a series of substituted 8-methylquinoline derivatives. Finally, this method was fully automated using a radiochemistry synthesis module. |
| Databáze: | OpenAIRE |
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