Lactose (mal)digestion evaluated by the 13 C-lactose digestion test
| Autor: | Y Lin, CY Huang, Roel J. Vonk, Jean-Michel Antoine, H. A. Koetse, G Zeng, Frans Stellaard, H Elzinga |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Breath test
medicine.medical_specialty Lactose intolerance medicine.diagnostic_test medicine.medical_treatment Clinical Biochemistry Lactase General Medicine medicine.disease Biochemistry Lactase activity Excretion chemistry.chemical_compound Endocrinology Animal science chemistry Internal medicine medicine Lactose Digestion Volunteer |
| Zdroj: | European Journal of Clinical Investigation. 30:140-146 |
| ISSN: | 0014-2972 |
| DOI: | 10.1046/j.1365-2362.2000.00609.x |
| Popis: | Background The prevalence of generically determined lactase nonpersistence is based on the results of the lactose H-2 breath rest. This test, however, is an indirect test, which might lead to misinterpretation. Design We determined lactase activity in healthy Chinese and Dutch students using a novel C-13-lactose digestion test. The cut-off value of this rest was established in a Chinese population with a homogenous genetic background of lactase nonpersistence and was compared with the results obtained in a Caucasian population Twenty-five grams of a C-13-lactose solution was consumed by 12 known H-2-positive and 5 H-2-negative Chinese students and 48 Dutch students and, subsequently, C-13-glucosc concentration in plasma and H-2 excretion in breath were measured. Results A similar C-13-glucose response curve was round in all Chinese students. The mean response curve in the Dutch students was more pronounced (P |
| Databáze: | OpenAIRE |
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