1676 CPAP DOES NOT ALTER CO2 SENSITIVITY
| Autor: | William W. Frayer, Alfred N. Krauss, V Alfero, P A M Auld, R Goldstein |
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| Rok vydání: | 1981 |
| Předmět: | |
| Zdroj: | Pediatric Research. 15:723-723 |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | CPAP has been proposed as an effective treatment for the apnea of prematurity. Its mechanism of action is unknown. Twentyfour preterm infants receiving CPAP for the treatment of respiratory distress were studied at 0,5,and 10cm H2O CPAP. These infants were allowed to breathe 2%,5%,and 8% CO2 for 3 minutes each. During the 3rd minute, recordings of tidal volume,respiratory rate, and esophageal pressure were made. From these recordings, minute volume,inspiratory time (Ti) ,expiratory time (Te), compliance, duty cycle (Ti/Ttot), tidal volume/inspiratory time ratio (Vt/Ti) and CO2 sensitivity were calculated. Although CO2 sensitivity rose from 3.9±6.8 cc/min x mm Hg-1 at 0 cm H2O of CPAP to 4.8±8.0 at 10 cm H2O, this difference was not statistically significant. Significant differences in respiratory rate, Ti, Te, Vt/Ti, and Ti/Ttot were not observed when values for all 3 levels of CPAP were compared. Measurements of intraesophageal pressure indicated that 62% of the applied airway pressure was transmitted to the mediastinal structures at 5 cm H2O and 54% of applied pressure at 10 cm H2O. These results suggest that in a group of premature infants with poor CO2 sensitivity that CPAP does not either improve CO2 sensitivity or the drive to breathe, and that other explanations, such as improvement in arterial blood gases or stabilization of the chest wall must account for the relief of apnea in infants receiving CPAP therapy. |
| Databáze: | OpenAIRE |
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