Evaluation of Telomere Length in Granulosa Cells; Effects of Ketogenic and Western Diet
| Autor: | Songul Doganay, Ayla Eren Ozdemir, Özcan Budak |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Both ovaries biology business.industry medicine.medical_treatment Stimulation Significant negative correlation biology.organism_classification BALB/c Telomere 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Apoptosis Internal medicine Western diet medicine business 030217 neurology & neurosurgery Ketogenic diet |
| Zdroj: | Medical Science and Discovery. 7:684-690 |
| ISSN: | 2148-6832 |
| DOI: | 10.36472/msd.v7i11.437 |
| Popis: | Objective: In this study, it was aimed to research the effects of nutrition with different diets on the telomere length of granulosa cells. Material and Methods: In the study, 21 BALB C female rats (in each group; n = 7) were divided into three groups as the standard diet group (SD), the ketogenic diet group (KD) and the western diet group. The animals in the SD group were fed with standard mouse feed, while the KD and WD groups were fed with specially prepared diets. At the end of the experiment, a controlled superovulation stimulation protocol was applied to both ovaries. Smear preparations were ready for telomere length (GLT) and apoptotic (caspase-3) evaluations from granulosa cells taken from oocytes collected from ovaries. Results: There was a negative correlation between GLT and body weight (r = -0.424; p = 0.056). However, this correlate was not statistically significant. At the end of the experiment, body weight was significantly higher in the WD group compared to the KD group (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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