Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling
Autor: | En-Sheng Ji, Jian-Xin Wang, Peng Guan, Lu-Yun Qin, Na Wang, Li-Fei Luo |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
biology business.industry Clinical chemistry Clinical Biochemistry Cardiomyopathy NOX4 Cell Biology General Medicine Traditional Chinese medicine Pharmacology GPX4 medicine.disease biology.organism_classification medicine.disease_cause 03 medical and health sciences Astragalus 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis medicine Myocardial fibrosis business Molecular Biology Oxidative stress |
Zdroj: | Molecular and Cellular Biochemistry. 476:2603-2611 |
ISSN: | 1573-4919 0300-8177 |
DOI: | 10.1007/s11010-021-04112-6 |
Popis: | Astragaloside IV (AsIV), an active ingredient isolated from traditional Chinese medicine astragalus membranaceus, is beneficial to cardiovascular health. This study aimed to characterize the functional role of AsIV against adriamycin (ADR)-induced cardiomyopathy. Here, healthy rats were treated with ADR and/or AsIV for 35 days. We found that AsIV protected the rats against ADR-induced cardiomyopathy characterized by myocardial fibrosis and cardiac dysfunction. Meanwhile, ADR increased type I and III collagens, TGF-β, NOX2, and NOX4 expression and SMAD2/3 activity in the left ventricles of rats, while those effects were countered by AsIV through suppressing oxidative stress. Moreover, ADR was found to promote cardiac ferroptosis, whereas administration of AsIV attenuated the process via activating Nrf2 signaling pathway and the subsequent GPx4 expression increasing. These results suggest that AsIV might play a protective role against ADR-induced myocardial fibrosis, which may partly attribute to its anti-ferroptotic action by enhancing Nrf2 signaling. |
Databáze: | OpenAIRE |
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