Polysuccinimide and its derivatives: Degradable and water soluble polymers (review)
| Autor: | Esmat Jalalvandi, Amin Shavandi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Polymers and Plastics Biocompatibility Organic Chemistry General Physics and Astronomy 02 engineering and technology Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Hydrolysis chemistry.chemical_compound Polymerization chemistry Reagent Amide Materials Chemistry Organic chemistry Polyaspartic acid 0210 nano-technology Polyimide |
| Zdroj: | European Polymer Journal. 109:43-54 |
| ISSN: | 0014-3057 |
| Popis: | Interest for water soluble polymers which show biocompatibility and degradability is growing due to their potential applications in medical sciences. Polysuccinimide (PSI), commonly synthesized through thermal polymerization, is a polyimide precursor for the production of such biocompatible and degradable polymers namely polyaspartic acid and various polyaspartamides. Polyaspartic acid is usually obtained by hydrolysis of PSI while polyaspartamide is produced by ring opening of PSI using a nucleophilic reagent. The presence of amide linkages in these polymers gives them peptide-like structures which is prone to hydrolysis and subsequent degradation. These derivatives could be potential substitutes for different polyamino acids in many medical applications. This review compiles the works carried out on developing polysuccinimide and its derivatives as well as the main synthetic routs and characterization methods. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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