Abstract TP187: Trimethylamine-N-oxide Values Are Increased in Patients With Acute Ischemic Stroke but Decrease Significantly Within the First Days
| Autor: | Christina Nürnberg, Kathrin V. Schwarz, Christine Schneider, Jürgen G. Okun, Jana Hauke, Péter Monostori, Sibu Mundiyanapurath |
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| Rok vydání: | 2019 |
| Předmět: |
Advanced and Specialized Nursing
medicine.medical_specialty business.industry Trimethylamine N-oxide Arteriosclerosis medicine.disease Gastroenterology Gut microbiome chemistry.chemical_compound chemistry Internal medicine medicine Biomarker (medicine) In patient Neurology (clinical) Microbiome Cardiology and Cardiovascular Medicine business Acute ischemic stroke Stroke |
| Zdroj: | Stroke. 50 |
| ISSN: | 1524-4628 0039-2499 |
| Popis: | Introduction: Trimethylamine-N-oxide (TMAO ) is a biomarker of the gut microbiome and has been reported to be associated with cardiovascular diseases. However, there have been conflicting reports regarding its association with ischemic stroke. As TMAO values could be elevated before stroke or change after stroke we aimed at analyzing the early time course of TMAO values after acute ischemic stroke. Methods: In this prospective ongoing case-control study, we included patients with ischemic stroke within the first 24 hours after last-seen-well and control patients treated for other neurologic disorders with only few cardiovascular risk factors at a tertiary care university hospital. The TMAO-values on admission and after 48 hours were analyzed. Patients and controls were excluded if they were treated with antibiotics within the last 30 days and if they were treated with probiotics or chemotherapy. Results: 99 patients have been recruited so far (63 stroke patients and 36 controls). The median NIHSS score in stroke patients was 3 (interquartile range: 1-8). 89% of the stroke patients vs. 94% of the control group had a normal kidney function. Stroke patient had significantly higher median TMAO values compared to control patients: 5.4 (3.0-8.0) vs. 2.8 (1.6-5.0) μmol/l, p=0.002. Interestingly, there was a significant decrease in TMAO values in stroke patients from admission to 48 hours after the stroke (median decrease 0.7 (0.6-4.2) p=0.004), which was not found for the control group (median decrease 0.1 (-0.9-1.3), p=0.758). In consequence, there was no significant difference between the groups for the TMAO-values after 48 hours (3.4 (2.5-5.1) vs. 3.0 (1.6-4.5) μmol/l, p=0.081). Conclusion: This study emphasizes the importance of the TMAO time course after stroke. TMAO values decrease dramatically within the first days after stroke which makes it essential to standardize the time point of analysis to ensure comparability in future studies. |
| Databáze: | OpenAIRE |
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