582-P: Triglycerides, Uric Acid, and Incidence of Type 2 Diabetes Mellitus in Northwest China: The Jinchang Cohort Study
| Autor: | Wenya Huang, Jingli Yang, Nian Liu, Yana Bai, Shan Zheng, Rui Zhang, Peiyao Huang, Ruonan Wang, Minzhen Wang, Zhao Bai, Ning Cheng |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
education.field_of_study business.industry Endocrinology Diabetes and Metabolism Population nutritional and metabolic diseases Type 2 Diabetes Mellitus medicine.disease Gastroenterology chemistry.chemical_compound chemistry Internal medicine Diabetes mellitus Cohort Internal Medicine Medicine Uric acid Hyperuricemia business education Prospective cohort study Cohort study |
| Zdroj: | Diabetes. 69 |
| ISSN: | 1939-327X 0012-1797 |
| Popis: | Objective: To study the association of triglycerides(TG), uric acid and incidence of type 2 diabetes mellitus(T2DM), evaluate whether there would be an additive interaction between two factors. Methods: Based on the follow-up population of Jinchang cohort, an ongoing occupational-based prospective cohort study of 48,001 participants at baseline, the nested-case control study was used to explore the relationship of TG, uric acid and incidence of T2DM, and calculate the odds ratio(OR) and 95% confidence intervals(CI). The interaction additive model was used to evaluate whether there would be an additive interaction between two factors. Results: Among 18,195 participants with normal fasting plasma glucose(FPG) at baseline, there were 267 incident diabetes cases during a median of 2.2 years of follow-up. With the increase of serum TG and uric acid, the cumulative incidences of diabetes in people with normal FPG at baseline were all rising (P for trend Conclusion: Increased triglycerides and uric acid were strong risk factors of diabetes. Furthermore, there was a positive additive interaction between hypertriglyceridemia and hyperuricemia on the development of diabetes from normal fasting plasma glucose. Disclosure W. Huang: None. J. Yang: None. N. Liu: None. P. Huang: None. R. Zhang: None. R. Wang: None. Z. Bai: None. N. Cheng: None. M. Wang: None. S. Zheng: None. Y. Bai: None. Funding National Institutes of Health (1R01ES02908201A1); Lanzhou University (2018LDBRZD008) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|