P3‐070: DETECTION OF PRE‐PLAQUE AMYLOID AGGREGATION USING FTIR
| Autor: | Oxana Klementieva, Anders Engdahl, Katarina Willén, Gunnar K. Gouras, Per Uvdal, Mathilde Faideau |
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| Rok vydání: | 2014 |
| Předmět: |
Epidemiology
Chemistry Health Policy Confocal food and beverages Psychiatry and Mental health Cellular and Molecular Neuroscience Protein structure Developmental Neuroscience Amyloid aggregation Microscopy Biophysics Extraction methods Neurology (clinical) Geriatrics and Gerontology Fourier transform infrared spectroscopy |
| Zdroj: | Alzheimer's & Dementia. 10 |
| ISSN: | 1552-5279 1552-5260 |
| DOI: | 10.1016/j.jalz.2014.05.1158 |
| Popis: | Background: Alzheimer's disease (AD) is characterized by misfolding and aggregation of naturally occurring beta-amyloid peptides (Aβ). These aggregates are thought to be pathogenic to neurons, although the conformation of the pathogenic Aβ species remains unclear. Biochemical extraction methods and different microscopy techniques (TEM, confocal) can be used to identify pathogenic Aβ species in the brain, although such methods can alter protein conformation or are n ot designed to determine structural details of protein assemblies. |
| Databáze: | OpenAIRE |
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