Iron-catalyzed hydroaminocarbonylation of alkynes to produce succinimides with NH4HCO3

Autor:	Zijun Huang, Jiyong Deng, Zilong Chen, Changsheng Tang, Shaofeng Pi, Yuehui Li, Zhengde Tan
Rok vydání:	2021
Předmět:	Chemistry Iron catalyzed Succinimide derivatives Physical and Theoretical Chemistry Combinatorial chemistry Iron catalyst Catalysis Succinimides
Zdroj:	Journal of Catalysis. 404:224-230
ISSN:	0021-9517
DOI:	10.1016/j.jcat.2021.09.035
Popis:	Succinimide derivatives are valuable compounds in synthesis of natural products and pharmaceuticals. A catalytic hydroaminocarbonylation reaction was developed for the synthesis of succinimides from alkynes, CO and NH4HCO3. The novel transformation proceeds in the presence of Fe3(CO)12 without the need for expensive ligands or additives. Various substituted alkynes are selectively transformed into corresponding succinimides in good yields. Preliminary mechanistic studies suggest that NH4HCO3 plays an important role in the formation and stabilization of iron catalyst.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d72632f3ab3f9881a9137e8581f215c8 https://doi.org/10.1016/j.jcat.2021.09.035 Zobrazit plný text záznamu Full Text from ScienceDirect