CSF Aβ1–42, but not p-Tau181, differentiates aMCI from SCI
| Autor: | Marcelle Maria Portal, Luciane Missiaggia, Matheus Roriz-Cruz, Carlos Eduardo Alves Batista, Liara Rizzi |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pathology Immunoenzymatic assay General Neuroscience Memory clinic Diagnostic accuracy Odds ratio behavioral disciplines and activities Gastroenterology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Internal medicine mental disorders Csf biomarkers medicine Neurology (clinical) Neuropsychological testing Verbal memory Cognitive impairment Psychology Molecular Biology 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Brain Research. 1678:27-31 |
| ISSN: | 0006-8993 |
| Popis: | Aim Individuals with amnestic mild cognitive impairment (aMCI) are at a high risk to develop Alzheimer’s disease (AD). We compared CSF levels of biomarkers of amyloidosis (Aβ1–42) and neurodegeneration (p-Tau181) in individuals with aMCI and with subjective cognitive impairment (SCI) in order to ascertain diagnostic accuracy and predict the odds ratio associated with aMCI. Methods We collected CSF of individuals clinically diagnosed with aMCI (33) and SCI (12) of a memory clinic of Southern Brazil. Levels of Aβ1–42 and p-Tau181 were measured by immunoenzymatic assay. Participants also underwent neuropsychological testing including the verbal memory test subscore of the Consortium to Establish a Registry for Alzheimer’s Disease (VM-CERAD). Results CSF concentration of Aβ1–42 was significantly lower (p: .007) and p-Tau181/Aβ1–42 ratio higher (p: .014) in aMCI individuals than in SCI. However, isolate p-Tau181 levels were not associated with aMCI (p: .166). There was a statistically significant association between Aβ1–42 and p-Tau181 (R2: 0.177; β: −4.43; p: .017). ROC AUC of CSF Aβ1–42 was 0.768 and of the p-Tau181/Aβ1–42 ratio equals 0.742. Individuals with Aβ1–42 0.071 were at 4.6 increased odds to have aMCI (p: .043), with a 64.5% accuracy. VM-CERAD was significantly lower in aMCI than among SCI (p: .041). Conclusion CSF Aβ1–42, but not p-Tau181, level was significantly associated with aMCI. |
| Databáze: | OpenAIRE |
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