Ameliorating Effects of Aqueous Extract of Tetracarpidium conophorhum against Iron- Overload Induced damage in Rats
Autor: | S.O. Innih, O. Ikponmwosa-Eweka, Nkeiruka Eluehike |
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Rok vydání: | 2020 |
Předmět: |
chemistry.chemical_classification
0303 health sciences Antioxidant medicine.medical_treatment Albumin Pharmacology Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Enzyme chemistry Oral administration 030220 oncology & carcinogenesis medicine Alkaline phosphatase Iron(II) chloride Liver function 030304 developmental biology |
Zdroj: | Journal of Applied Sciences and Environmental Management. 24:681-689 |
ISSN: | 2659-1502 1119-8362 |
DOI: | 10.4314/jasem.v24i4.21 |
Popis: | Iron, though an important nutrient but in excess can produce serious damaging effects on organs of the body. Intake of plants and or plant products with iron chelating ability, instead of synthetic iron chelators, can produce less adverse effects and may be more effective. The potential effect of Tetracarpidium conophorhum (T. conophorhum) as a chelating agent of plant origin has not been determined hence the present study. Iron overload condition was induced by oral administration of iron II chloride in the rats. Twenty five rats were randomly divided into five groups. Groups A and B were the normal and negative control (iron overload only) respectively. Groups C-E were the iron overload induced rats treated with 250, 500 and 1000mg/kg body weight of T. conophorhum extracts. Animals in groups C-E received daily oral administration of extracts for thirty days. Thereafter, we studied the effects of T. conophorhum on liver function enzymes, antioxidant enzymes, hematological parameters and lipidperoxidation. Iron overloaded rats showed significant increase (p |
Databáze: | OpenAIRE |
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