Stellenwert der Hirnparenchym-Sonografie in der Differenzial- und Frühdiagnose des Parkinson-Syndroms
| Autor: | K. Del Tredici, Johann Hagenah, Daniela Berg, W. Fogel, Wolfgang H. Oertel, Dirk Woitalla, Heiko Braak |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty Parkinson's disease Movement disorders medicine.diagnostic_test Echogenicity Context (language use) Substantia nigra Physical examination medicine.disease nervous system diseases Transcranial Doppler Psychiatry and Mental health nervous system Neurology medicine Neurology (clinical) Differential diagnosis medicine.symptom Psychology |
| Zdroj: | Fortschritte der Neurologie · Psychiatrie. 78:S25-S30 |
| ISSN: | 1439-3522 0720-4299 |
| DOI: | 10.1055/s-0029-1245167 |
| Popis: | Imaging of the brain structure with transcranial ultrasound has become an important tool for the diagnosis and differential diagnosis of Parkinson's Disease. In up to 90 % of parkinsonian patients abnormal echogenity of the substantia nigra could be demonstrated. Particularly in the early diagnosis in subjects with only very mild extrapyramidal features and in the differential diagnosis to other neurodegenerative disorders with parkinsonian features, such as the parkinsonian variant of multisystematrophy (MSA-P) and progressive supranuclear paralysis (PSP) ultrasound has a high diagnostic yield. Because of a prevalence of about 10 % in the normal population, the evidence of an abnormal echogenity of the substantia nigra has to be interpreted carefully in the context of a clinical examination. Although there are a number of studies indicating that in some of these subjects a vulnerability of the nigrostriatal system can be found, the meaning of an abnormal echogenicity of the substantia nigra in the healthy population needs to be further elucidated in already ongoing research projects. |
| Databáze: | OpenAIRE |
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