Inhibition of rosette formation by antithymocyte globulin

Autor:	Stephen Krauss, John A. MacGuire, Albert T. Ichiki, Kathy L. Wenzel, I. Reid Collmann, Takuo Sonoda
Rok vydání:	1977
Předmět:	Cancer Research education.field_of_study Globulin biology Colorectal cancer business.industry Immunology Population Clinical course medicine.disease Titer Oncology Rosette formation medicine biology.protein Immunology and Allergy Adenocarcinoma Immunocompetence business education
Zdroj:	Cancer Immunology Immunotherapy. 3
ISSN:	1432-0851 0340-7004
DOI:	10.1007/bf00200069
Popis:	The peripheral blood leukocytes from 29 patients with adenocarcinoma of the colon were studied sequentially for the T-cell level, the rosette-inhibition titer of antithymocyte globulin and the blastogenic response to PHA and Con A to evaluate the T-cell immunocompetence. The level of E-rosette-forming cells and the blastogenic response did not reflect the immunocompetence of the T-cell population. Fluctuations in the rosette-inhibition titer of antithymocyte globulin (ATG) were observed; an increased ATG titer indicated an unfavorable clinical course, while a decreased ATG titer was observed with patients who had a favorable clinical course. The rosette-inhibition titer with antithymocyte globulin was observed to be an important indicator of competent T cells in patients with colorectal cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d6f6cbcc2e659bf828ebc072306afc96 https://doi.org/10.1007/bf00200069 Zobrazit plný text záznamu Full text from SpringerLink