Prepare several substituted pyridines derived from Chalcone and evaluate their bioactivity

Autor:	Baraa Basem Mayah Muhammad, Khaled Abdel Aziz Attia Al Badrani
Rok vydání:	2022
Předmět:	General Nursing Education
Zdroj:	International journal of health sciences. :11556-11564
ISSN:	2550-696X 2550-6978
DOI:	10.53730/ijhs.v6ns5.11157
Popis:	In this research, Chalcone (M1-10) was prepared by reaction of aromatic aldehydes with substituted acetophenone, through reaction of Chalcone with Malononitrile in an acidic medium, where pyridine compounds (M19-26) were obtained. The bioactivity of the prepared compounds was tested against Gram-negative and Gram-positive bacteria (Klebsellia pneumonia, Pseudomnas putida, Staph aureus, Enterococcus faecalis). the lowest inhibitory concentration compared to (Ciprofloxacin) and the prepared compounds were diagnosed by physical spectrophotometric methods using spectrophotometers. I.R, 1H-NMR, 13C-NMR.
Databáze:	OpenAIRE
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